The Genetic Architecture of Alopecia Areata

The genetic architecture of alopecia areata.

A major impetus to initiating the Human Genome Project was the belief that information encoded in the human genome would "accelerate progress in understanding disease pathogenesis and in developing new approaches to diagnosis, treatment, and prevention in many areas of medicine". Alopecia areata (AA) is a notable example of how understanding the genetic basis of a disease can have an impact on ...

Alopecia areata.

n engl j med 367;3 nejm.org july 19, 2012 279 methacin should be used in addition to pancre­ atic stents in high­risk patients. However, post hoc analysis of our trial suggests that indometha­ cin may obviate the need for prophylactic pan­ creatic stent placement (unpublished data), and we therefore agree with Baron et al. that com­ parative effectiveness studies of indomethacin and pancreatic ...

Alopecia areata.

Alopecia areata is a frequent cause of hair loss. The origin of disease is not fully understood. However there are indications for a T-cell mediated autoimmune process. Genetic, immunologic and psychologic factors are important for the outbreak of disease. Most patients show localized patches of acute hair loss, where regrowth is observed spontaneously or with simple topical treatment within fe...

Alopecia Areata

Management of alopecia areata

Epithelial Sciences, School of Translational Medicine, University of Manchester, Manchester Jackson Laboratory, Bar Harbor, ME, USA Department of Dermatology, China-Japan Union Hospital of JiLin University, Chang Chun, People’s Republic of China Department of Dermatology, University of Lübeck, D-23538 Lübeck, Germany Skin Disease Research Centre, Division of Dermatology, Vanderbilt Medical Cent...